ProSci

ARHGAP18 Antibody

Product Code:
 
PSI-5589
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunofluorescence (IF)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
1 / 3
Western blot analysis of ARHGAP18 in 3T3 cell lysate with ARHGAP18 antibody at (A) 1 and (B) 2 μg/mL.
2 / 3
Immunocytochemistry of ARHGAP18 in 3T3 cells with ARHGAP18 antibody at 2.5 μg/mL.
3 / 3
Immunofluorescence of ARHGAP18 in 3T3 cells with ARHGAP18 antibody at 20 μg/mL.
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Western blot analysis of ARHGAP18 in 3T3 cell lysate with ARHGAP18 antibody at (A) 1 and (B) 2 μg/mL.
Immunocytochemistry of ARHGAP18 in 3T3 cells with ARHGAP18 antibody at 2.5 μg/mL.
Immunofluorescence of ARHGAP18 in 3T3 cells with ARHGAP18 antibody at 20 μg/mL.

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CodeSizePrice
PSI-5589-0.02mg0.02mg£150.00
Quantity:
PSI-5589-0.1mg0.1mg£449.00
Quantity:
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Further Information

Additional Names:
ARHGAP18 Antibody: SENEX, MacGAP, bA307O14.2, Rho GTPase-activating protein 18
Application Note:
ARHGAP18 antibody can be used for detection of ARHGAP18 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunocytochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.

Antibody validated: Western Blot in mouse samples; Immunocytochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
Background:
ARHGAP18 Antibody: ARHGAP18 is one member of the human RhoGAP family with approximately 80 RhoGAP proteins known to be encoded in the human genome. Rho proteins belong to the Ras superfamily that is composed of over 50 members divided into six families, including Ras, Sar, Rho, Ran, Rab and Arf. Rho GTPases are important regulators of the actin cytoskeleton and consequently influence the shape and migration of cells. ARHGAP18 is linked to Ras, and thus, to EGFR-mediated proliferation, migration and differentiation. ARHGAP18 is precisely contained within chromosome 6q22-24, which has been shown to be linked to schizophrenia, suggesting that ARHGEP18 may play a role in this condition.
Background References:
  • Takai Y, Sasaki T, and Matozaki T. Small GTP-binding proteins. Physiol. Rev.2001; 81:153-208.
  • Potkin SG, Turner JA, Fallon JA, et al. Gene discovery through imaging genetics: identification of two novel genes associated with schizophrenia. Mol. Psychiatry2009; 14:416-28.
Buffer:
ARHGAP18 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
ARHGAP18 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human ARHGAP18.

The immunogen is located within the last 50 amino acids of ARHGAP18.
NCBI Gene ID #:
93663
NCBI Official Name:
Rho GTPase activating protein 18
NCBI Official Symbol:
ARHGAP18
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_277050
Protein GI Number:
39932589
Purification:
ARHGAP18 Antibody is affinity chromatography purified via peptide column.
Research Area:
Signal Transduction
Swissprot #:
Q8N392
User NOte:
Optimal dilutions for each application to be determined by the researcher.