ProSci

IA-6 Antibody

Product Code:
 
PSI-5417
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
1 / 1
Western blot analysis of IA-6 in rat thymus tissue lysate with IA-6 antibody at (A) 1 and (B) 2 μg/mL.
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Western blot analysis of IA-6 in rat thymus tissue lysate with IA-6 antibody at (A) 1 and (B) 2 μg/mL.

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CodeSizePrice
PSI-5417-0.02mg0.02mg£150.00
Quantity:
PSI-5417-0.1mg0.1mg£449.00
Quantity:
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Further Information

Additional Names:
IA-6 Antibody: IA6, IA-6, mlt1, IA6, Nbla106, Insulinoma-associated protein 2, Zinc finger protein IA-6
Application Note:
IA-6 antibody can be used for detection of IA-6 by Western blot at 1 - 2 μg/mL.

Antibody validated: Western Blot in rat samples. All other applications and species not yet tested.
Background:
IA-6 Antibody: IA-6, also known as insulinoma-associated 2 or INSM2, is related to IA-1 (INSM1), a zinc-finger factor that is expressed in the developing nervous system. While the exact function of IA-6 is not known, other related insulinoma-associated proteins such as IA-2 are major autoantigens in type 1 diabetes. The homology exhibited by IA-6 to IA-1 has led to speculation that IA-6 may also play a role in the regulation of gene transcription.
Background References:
  • Ota T, Suzuki Y, Nishikawa T, et al. Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet.2004; 36:40-5.
  • Wildner H, Gierl MS, Strehle M, et al. Insm (IA-1) is a crucial component of the transcriptional network that controls differentiation of the sympathoadrenal lineage. Dev.2008; 135:473-81.
  • Trembleau S, Penna G, Grigori S, et al. Early Th1 response in unprimed nonobese diabetic mice to the tyrosine phosphatase-like insulinoma-associated protein 2, an autoantigen in type 1 diabetes. J. Immunol.2000; 165:6748-55.
Buffer:
IA-6 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
IA-6 antibody was raised against a 14 amino acid synthetic peptide from near the carboxy terminus of human IA-6.

The immunogen is located within amino acids 340 - 390 of IA-6.
NCBI Gene ID #:
84684
NCBI Official Name:
insulinoma-associated 2
NCBI Official Symbol:
INSM2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
AAI30380
Protein GI Number:
120659844
Purification:
IA-6 Antibody is affinity chromatography purified via peptide column.
Research Area:
Cancer
Swissprot #:
Q96T92
User NOte:
Optimal dilutions for each application to be determined by the researcher.