ProSci

Prosapip2 Antibody

Product Code:
 
PSI-5397
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunofluorescence (IF)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
1 / 3
Western blot analysis of Prosapip2 in rat liver tissue lysate with Prosapip2 antibody at 1 μg/mL.
2 / 3
Immunohistochemistry of Prosapip2 in rat liver tissue with Prosapip2 antibody at 5 μg/mL.
3 / 3
Immunofluorescence of Prosapip 2 in rat liver tissue with Prosapip 2 antibody at 20 μg/mL.
❮❯

Western blot analysis of Prosapip2 in rat liver tissue lysate with Prosapip2 antibody at 1 μg/mL.
Immunohistochemistry of Prosapip2 in rat liver tissue with Prosapip2 antibody at 5 μg/mL.
Immunofluorescence of Prosapip 2 in rat liver tissue with Prosapip 2 antibody at 20 μg/mL.

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CodeSizePrice
PSI-5397-0.02mg0.02mg£150.00
Quantity:
PSI-5397-0.1mg0.1mg£449.00
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Further Information

Additional Names:
Prosapip2 Antibody: SINTBAD, ProSAPiP2, KIAA0775, SINTBAD, TANK-binding kinase 1-binding protein 1, TBK1-binding protein 1
Application Note:
Prosapip2 antibody can be used for detection of Prosapip2 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.

Antibody validated: Western Blot in rat samples; Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.
Background:
Prosapip2 Antibody: Prosapip2 (TBKBP1) is essential for signal transduction during viral infection thus plays a major role in the TNF/NF-κB pathway. It is an adaptor protein that constitutively binds TBK1 (TANK-binding kinase) and IKBKE and may play a role in antiviral innate immunity. Prosapip2 is a 615 amino acid adaptor protein belonging to the fibrillar collagen family, consisting of trimers of identical alpha 1 chains which are linked to each other by interchain disulfide bonds. It has a ubiquitous expression with highest levels in ovary, followed by the neuronal system. Prosapip2 binds to TBK1 and helps in the activation of IRF3 which controls the expression of antiviral genes during infection. Recent studies show that Prosapip2 is an interaction partner of ProSAP2/Shank3 and actin, suggesting a role as a linker molecule between postsynaptic density and the cytoskeleton.
Background References:
  • Bouwmeester T, Bauch A, Ruffner H, et al. A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. Nat. Cell Biol.2004; 6:97-105
  • Ryzhakov G and Randow F. SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK. EMBO J.2007; 26:3180-90.
  • Meffert MK, Chang JM, Wiltgen BJ, et al. NF-kappa B functions in synaptic signaling and behavior. Nat. Neurosci.2003; 6:1072-78.
  • Liebau S, Proepper C, Schmidt T, et al. ProSAPiP2, a novel postsynaptic density protein that interacts with ProSAP2/Shank3. Biochem. Biophys. Res Commun.2009; 385:460-5.
Buffer:
Prosapip2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Prosapip2 antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human Prosapip2.

The immunogen is located within amino acids 500 - 550 of Prosapip2.
NCBI Gene ID #:
9755
NCBI Official Name:
TBK1 binding protein 1
NCBI Official Symbol:
TBKBP1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_055541
Protein GI Number:
7662302
Purification:
Prosapip2 Antibody is affinity chromatography purified via peptide column.
Research Area:
Innate Immunity
Swissprot #:
A7MCY6
User NOte:
Optimal dilutions for each application to be determined by the researcher.