Further Information
LRFN3 Antibody: SALM4, FIGLER1, SALM4, UNQ5865/PRO34192, Leucine-rich repeat and fibronectin type-III domain-containing protein 3, Synaptic adhesion-like molecule 4
LRFN3 antibody can be used for detection of LRFN3 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
LRFN3 Antibody: LRFN3 is one of a family of five transmembrane glycoproteins that are highly expressed in neuronal tissues. LRFN proteins share leucine-rich repeat (LRR)-immunoglobulin-like (Ig)-fibronectin type III (Fn)-transmembrane domain structure with other members of the LRR-Ig-Fn protein superfamily such as the Slitrk family of proteins. Expression of LRFN1, -3, and -4 mRNA was detected in embryonic neuronal cells, while Lrfn2 and Lrfn5 expression was primarily restricted to more mature cells. LRFN1, -2, and -4 bound to PDZ domains of postsynaptic PSD95, re-distributing PSD95 to the cell periphery. It has been suggested that the Lrfn proteins play a role in the developing and/or mature vertebrate nervous system.
- Morimura N, Inoue T, Katayama K, et al. Comparative analysis of structure, expression and PSD95-binding capacity of Lrfn, a novel family of neuronal transmembrane proteins. Gene2006; 380:72-83.
- Kobe B and Kajava AV. The leucine-rich repeat as a protein recognition motif. Curr. Opin. Struct. Biol.2001; 11:725-32.
- Aruga J and Mikoshiba K. Identification and characterization of Slitrk, a novel transmembrane protein family controlling neurite outgrowth. Mol. Cell Neurosci.2003; 24:117-29.
LRFN3 Antibody is supplied in PBS containing 0.02% sodium azide.
1 mg/mL
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Predicted species reactivity based on immunogen sequence: Bovine: (93%)
LRFN3 antibody was raised against a 16 amino acid synthetic peptide near the center of human LRFN3.
The immunogen is located within amino acids 380 - 430 of LRFN3.
79414
leucine rich repeat and fibronectin type III domain containing 3
LRFN3
Homo sapiens
Liquid
NP_078785
13375646
LRFN3 Antibody is affinity chromatography purified via peptide column.
Neuroscience
This antibody is predicted to not cross-react with other members of the LRFN family.
Q9BTN0
Optimal dilutions for each application to be determined by the researcher.