ProSci

Avian Influenza A M2 Antibody

Product Code:
 
PSI-4333
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Application:
 
Enzyme-Linked Immunosorbent Assay (ELISA)
 

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CodeSizePrice
PSI-4333-0.02mg0.02mg£150.00
Quantity:
PSI-4333-0.1mg0.1mg£449.00
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Further Information

Additional Names:
Avian Influenza A M2 Antibody:
Application Note:
M2 antibody can be used for the detection of the M2 protein from the H5N1 strain of avian influenza A in ELISA. It will detect 10 ng of free peptide at 1 mg/mL.
Background:
Avian Influenza A M2 Antibody: Influenza A virus is a major public health threat, killing more than 30, 000 people per year in the USA. Novel influenza virus strains caused by genetic drift and viral recombination emerge periodically to which humans have little or no immunity, resulting in devastating pandemics. Influenza A can exist in a variety of animals; however, it is in birds that all subtypes can be found. These subtypes are classified based on the combination of the virus coat glycoproteins hemagglutinin (HA) and neuraminidase (NA) subtypes. During 1997, an H5N1 avian influenza virus was determined to be the cause of death in 6 of 18 infected patients in Hong Kong. The more recent virulent strain of H5N1 is now seen in Africa and Europe, as well as in Southeast Asia. There is some evidence of human to human spread of this virus, but it is thought that the transmission efficiency was fairly low. The influenza membrane ion channel (M2) is a small transmembrane protein that regulates the pH inside the virion during viral entry into the cell and protects the newly synthesized hemagglutinin during their transport through low pH cellular compartments. It has been suggested as a target of neutralizing antibodies.
Background References:
  • Thompson WW, Shay DK, Weintraub, et al. Mortality associated with influenza and respiratory syncytial virus in the United States. JAMA2003; 289:179-186.
  • Alexander DJ. A review of avian influenza. Proceedings of the European Society for Veterinary Virology (ESVV) Symposium on Influenza Viruses of Wild and Domestic Animals. Vet. Microbiol.2000; 74:3-13.
  • Shortridge KF, Zhou NN, Guan Y, et al. Characterization of avian H5N1 influenza viruses from poultry in Hong Kong. Virol.1998; 252:331-342.
  • Buxton Bridges C, Katz JM, Seto WH, et al. Risk of influenza A (H5N1) infection among health care workers exposed to patients with influenza A (H5N1), Hong Kong. J. Inf. Dis.2000; 181:344-8.
Buffer:
Avian Influenza A M2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
M2 antibody was raised against a 13 amino acid synthetic peptide from amino terminus of H5N1 M2.

The immunogen is located within the first 50 amino acids of Avian Influenza A M2.
NCBI Official Name:
membrane ion channel 2
NCBI Official Symbol:
M
NCBI Organism:
Influenza A virus (A/chicken/Hebei/326/2005(H5N1))
Physical State:
Liquid
Protein Accession #:
ABC74394
Protein GI Number:
85692681
Purification:
Avian Influenza A M2 Antibody is affinity chromatography purified via peptide column.
Research Area:
Infectious Disease
Swissprot #:
Q2L7I8
User NOte:
Optimal dilutions for each application to be determined by the researcher.