ProSci

STEAP3 Antibody

Product Code:
 
PSI-4311
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunofluorescence (IF)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
1 / 3
Western blot analysis of STEAP3 in HeLa cell lysate with STEAP3 antibody at (A) 1 and (B) 2 μg/mL.
2 / 3
Immunohistochemistry of STEAP3 in mouse liver tissue with STEAP3 antibody at 2.5 μg/mL.
3 / 3
Immunofluorescence of STEAP3 in Mouse Liver cells with STEAP3 antibody at 20 μg/mL.
❮❯

Western blot analysis of STEAP3 in HeLa cell lysate with STEAP3 antibody at (A) 1 and (B) 2 μg/mL.
Immunohistochemistry of STEAP3 in mouse liver tissue with STEAP3 antibody at 2.5 μg/mL.
Immunofluorescence of STEAP3 in Mouse Liver cells with STEAP3 antibody at 20 μg/mL.

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CodeSizePrice
PSI-4311-0.02mg0.02mg£150.00
Quantity:
PSI-4311-0.1mg0.1mg£449.00
Quantity:
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Further Information

Additional Names:
STEAP3 Antibody: STMP3, TSAP6, AHMIO2, dudlin-2, Metalloreductase STEAP3, Dudulin-2, hTSAP6
Application Note:
STEAP3 antibody can be used for detection of STEAP3 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.

Antibody validated: Western Blot in human samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
Background:
STEAP3 Antibody: The six-transmembrane epithelial antigen of prostate 3 (STEAP3) is a member of a family of metalloreductases identified as cell-surface antigens in prostate tissue. Similar to two other members of the STEAP family (STEAP 2 and STEAP4), STEAP3 promotes both iron and copper reduction. STEAP3 is highly expressed in hematopoietic tissues and colocalizes with the transferrin endosome. Overexpression of STEAP3 stimulates iron reduction; mice lacking STEAP3 are deficient in erythroid ferrireductase activity, suggesting that STEAP3 is an endosomal ferrireductase required for transferrin-dependent iron uptake in erythroid cells.
Background References:
  • Ohgami RS, Campagna DR, Greer EL, et al. Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Nat. Genet.2005; 37:1264-9.
  • Ohgami RS, Campagna DR, McDonald A, et al. The Steap proteins are metalloreductases. Blood2006; 108:1388-94.
  • Graham RM, Chua ACG, Herbison CE, et al. Liver iron transport. World J. Gastroenterol.2007; 13:4725-36.
Buffer:
STEAP3 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
STEAP3 antibody was raised against a 15 amino acid synthetic peptide from near the amino terminus of human STEAP3.

The immunogen is located within the first 50 amino acids of STEAP3.
NCBI Gene ID #:
55240
NCBI Official Name:
STEAP family member 3
NCBI Official Symbol:
STEAP3
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 55 kDa

Observed: 51 kDa
Protein Accession #:
AAH95421
Protein GI Number:
127801437
Purification:
STEAP3 Antibody is affinity chromatography purified via peptide column.
Research Area:
Homeostasis
SPECIFICITY:
This STEAP3 antibody does not cross-react with other STEAP proteins.
Swissprot #:
Q658P3
User NOte:
Optimal dilutions for each application to be determined by the researcher.