Further Information
BAP31 Antibody: CDM, DDCH, BAP31, 6C6-AG, DXS1357E, B-cell receptor-associated protein 31, 6C6-AG tumor-associated antigen, BCR-associated protein 31
WB: 0.5-2 μg/mL; IHC: 2 μg/mL.
Antibody validated: Western Blot in human, mouse and rat samples; Immunohistochemistry in rat samples. All other applications and species not yet tested.
BAP31 Antibody: Bap31 and the related protein Bap29 are endoplasmic reticulum (ER) and ER-vesicle membrane proteins and members of the B-cell receptor-associated protein family. These two proteins are highly homologous and can form homo- and heterodimers. Bap31 is thought to be involved in the intracellular trafficking of several molecules such as MHC Class I molecules and CD11b/CD18. It may also play a role in the initiation of ER stress-induced apoptosis through its association with caspase-8 via a death effector domain in its cytoplasmic tail, possibly through the promotion of membrane fragmentation and the release of cytochrome c from mitochondria. Bap31 itself contains two caspase cleavage sites and is cleaved during apoptosis. The p20 fragment of Bap31, when expressed ectopicially, is also a potent inducer cell death.
- Ng et al. J. Cell Biol.1997; 139:327-38.
- Kim et al. EMBO J.1994; 13:3793-800.
- Paquet et al. J. Immunol.2004; 172:7548-55.
- Zen et al. J. Biol. Chem.2004; 279:44924-30.
BAP31 Antibody is supplied in PBS containing 0.02% sodium azide.
1 mg/mL
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Anti-BAP31 antibody (3665) was raised against a peptide corresponding to 17 amino acids near the carboxy terminus of human BAP31.
The immunogen is located within the last 50 amino acids of BAP31.
Human BAP31 has 2 isoforms, including isoform 1 (246aa, 28kD) and isoform 2 (313aa, 34.8kD). Mouse BAP31 has one isoform (245aa, 28kD) and Rat BAP31 also has one isoform (245aa, 28kD). 3665 can detect human, mouse and rat.
10134
B-cell receptor-associated protein 31
BCAP31
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 28kD
Observed: 28kD
NP_005736
32171186
BAP31 Antibody is affinity chromatography purified via peptide column.
Signal Transduction,
P51572
Optimal dilutions for each application to be determined by the researcher.