ProSci

West Nile Virus Matrix Antibody

Product Code:
 
PSI-3429
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Application:
 
Enzyme-Linked Immunosorbent Assay (ELISA)
 

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CodeSizePrice
PSI-3429-0.02mg0.02mg£150.00
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PSI-3429-0.1mg0.1mg£449.00
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Further Information

Additional Names:
West Nile Virus Matrix Antibody: Genome polyprotein, Core protein, NS1
Application Note:
West Nile virus matrix antibody can be used for the detection of the West Nile virus matrix precursor protein in ELISA. It will detect 10 ng of free peptide at 1 μg/mL.
Background:
West Nile Virus Matrix Antibody: West Nile Virus (WNV) is a member of the Flaviviridae, a plus-stranded virus family that includes St. Louis encephalitis virus, yellow fever virus, and Dengue virus. WNV was initially isolated in 1937 in the West Nile region of Uganda and has become prevalent in Africa, Asia, and Europe. It has rapidly spread across the United States with cases being observed in every continental state. Virus particles consist of a dense core made up of the core/capsid protein encapsulating the RNA genome surrounded by a membrane envelope embedded with envelope and matrix proteins. However, when the viruses are inside of infected cells, the matrix protein exists in its "pre-M" form as a heterodimer with the envelope proteins. Cleavage of the "pre-M" protein to its mature form occurs during release of the virus; this cleavage leas to the dissociation of the heterodimers. The WNV receptor has recently been identified as alpha v beta 3 integrin.
Background References:
  • Gould LH and Fikrig E. West Nile virus: a growing concern. J. Clin. Invest. 2004; 113:1102-7.
  • Wengler G and Wengler G. Cell-associated West Nile flavivirus is covered with E+pre-M protein heterodimers which are destroyed and reorganized by proteolytic cleavage during virus release. J. Virol. 1989; 2521-6.
  • Chu JJ and Ng ML. Interaction of West Nile virus with α v β 3 integrin mediates virus entry into cells. J. Biol. Chem. 2004; 279:54533-41.
Buffer:
West Nile Virus Matrix Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
West Nile virus matrix antibody was raised against a synthetic peptide corresponding to 15 amino acids near the middle of the west nile virus matrix precursor protein.

The immunogen is located within amino acids 190 - 240 of West Nile Virus Matrix.
NCBI Gene ID #:
912267
NCBI Official Name:
PreM protein
NCBI Official Symbol:
WNVgp1
NCBI Organism:
West Nile virus
Physical State:
Liquid
Protein Accession #:
NP_776012
Protein GI Number:
27735300
Purification:
West Nile Virus Matrix Antibody is affinity chromatography purified via peptide column.
Research Area:
Infectious Disease
Swissprot #:
P06935
User NOte:
Optimal dilutions for each application to be determined by the researcher.