ProSci

KLHL1 Antibody

Product Code:
 
PSI-3015
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
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Western blot analysis of KLHL1 in HeLa cell lysate with KLHL1 antibody at (A) 2 and (B) 4 μg/mL.
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Immunohistochemistry of KLHL1 in rat brain tissue with KLHL1 antibody at 10 μg/mL.
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Western blot analysis of KLHL1 in HeLa cell lysate with KLHL1 antibody at (A) 2 and (B) 4 μg/mL.
Immunohistochemistry of KLHL1 in rat brain tissue with KLHL1 antibody at 10 μg/mL.

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CodeSizePrice
PSI-3015-0.02mg0.02mg£150.00
Quantity:
PSI-3015-0.1mg0.1mg£449.00
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Further Information

Additional Names:
KLHL1 Antibody: MRP2, KIAA1490, Kelch-like protein 1
Application Note:
KLHL1 antibody can be used for the detection of KLHL1 by Western blot at 2 - 4 μg/mL. Antibody can also be used for immunohistochemistry starting at 10 μg/mL.

Antibody validated: Western Blot in human samples and Immunohistochemistry in rat samples. All other applications and species not yet tested.
Background:
KLHL1 Antibody: The mammalian Kelch-like 1 (KLHL1) was initially discovered as a homolog to the Drosophila Kelch gene that is highly expressed in several brain tissues. The predicted protein domain structure of KLHL1 is characteristic of a number of proteins that bind actin, form dimers, and often act as actin-organizing proteins. Based on the presence of anti-sense RNA that spans the transcription and translation start sites as well as the first splice site of KLHL1 in brain tissue of individuals suffering from the neurodegenerative disorder spinocerebellar ataxia type 8 (SCA8), it has been suggested that KLHL1 is involved this disease and that regulation of KLHL1 protein may be affected by antisense RNA expression.
Background References:
  • Nemes JP, Benzo KA, and Koob MD. The SCA8 transcript is an antisense RNA to a brain-specific transcript encoding a novel actin-binding protein (KLHL1). Human Mol. Gen. 2000; 9:1543-51.
  • Adams J, Kelso R, and Cooley L. The kelch repeat superfamily of proteins: propellers of cell function. Trends Cell Biol. 2000; 10:17-24.
  • Robinson DN and Cooley L. Drosophila kelch is an oligomeric ring canal actin organizer. J. Cell Biol. 1997; 138:799-810.
Buffer:
KLHL1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse: (100%)
Immunogen:
KLHL1 antibody was raised against a 14 amino acid synthetic peptide from near the amino-terminus of human KLHL1.

The immunogen is located within the first 50 amino acids of KLHL1.
NCBI Gene ID #:
57626
NCBI Official Name:
kelch-like 1 (Drosophila)
NCBI Official Symbol:
KLHL1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 82 kDa

Observed: 82 kDa
Protein Accession #:
AAF81719
Protein GI Number:
8926179
Purification:
KLHL1 Antibody is immunoaffinity purified .
Research Area:
Neuroscience
Swissprot #:
Q9NR64
User NOte:
Optimal dilutions for each application to be determined by the researcher.