ProSci

IL-22 Receptor Antibody

Product Code:
 
PSI-2489
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
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Western blot analysis of IL-22 Receptor expression in human HepG2 cell lysate with IL-22 Receptor antibody at 1 μg/ml.
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Western blot analysis of IL-22 Receptor expression in human HepG2 cell lysate with IL-22 Receptor antibody at 1 μg/ml.

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CodeSizePrice
PSI-2489-0.02mg0.02mg£150.00
Quantity:
PSI-2489-0.1mg0.1mg£449.00
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Further Information

Additional Names:
IL-22 Receptor Antibody: IL22R, CRF2-9, IL22R1, IL22R, Interleukin-22 receptor subunit alpha-1, Cytokine receptor class-II member 9, IL-22 receptor subunit alpha-1
Application Note:
IL-22 receptor antibody can be used for detection of IL-22 receptor by Western blot at 1 μg/mL. An approximately 62 kDa band can be detected.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Background:
IL-22 Receptor Antibody: A novel cytokine, designated IL-TIF for IL-10 related T cell-derived inducible factor and IL-22, was recently identified. The receptor for IL-22 (IL-22R, also termed CRF2-9 and IL-TIF-R1 chain) is a new member of the class II cytokine receptor family. IL-22R forms a complex with IL-10 receptor beta chain and mediates IL-22 signaling. IL-22 and its receptor activate JAK-STAT signaling pathway. IL22R is expressed in normal liver and kidney and their cell lines HepG2 and TK-10. A soluble form of IL-22 receptor, also termed IL-22 binding protein (IL-22BP) and IL-22 receptor-alpha 2 (IL-22RA2), was identified very recently. IL-22BP prevents binding of IL-22 to the functional cell surface IL-22R complex and neutralizes IL-22 activity. LPS induces IL-22 expression, which indicates the role of IL-22 in inflammatory response.
Background References:
  • Dumoutier L, Louahed J, Renauld JC. Cloning and characterization of IL-10-related T cell-derived inducible factor (IL-TIF), a novel cytokine structurally related to IL-10 and inducible by IL-9. J Immunol. 2000;164(4):1814-9.
  • Dumoutier L, Van Roost E, Colau D, Renauld JC. ?Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte-stimulating factor. Proc Natl Acad Sci USA. 2000 ;97(18):10144-9.
  • Xie MH, Aggarwal S, Ho WH, et al. Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R. J Biol Chem. 2000;275(40):31335-9.
  • Kotenko SV, Izotova LS, Mirochnitchenko OV, et al. Identification of the functional interleukin-22 (IL-22) receptor complex: J Biol Chem. 2001;276(4):2725-32.
Buffer:
IL-22 Receptor Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/ml
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine: (100%), Mouse: (93%)
Immunogen:
IL-22 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human IL-22.

The immunogen is located within the last 50 amino acids of IL-22 Receptor.
NCBI Gene ID #:
58985
NCBI Official Name:
interleukin 22 receptor, alpha 1
NCBI Official Symbol:
IL22RA1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
62 kDa
Protein Accession #:
AF286095
Protein GI Number:
10719607
Purification:
IL-22 Receptor Antibody is affinity chromatography purified via peptide column.
Research Area:
Chemokines & Cytokines
Swissprot #:
Q8N6P7
User NOte:
Optimal dilutions for each application to be determined by the researcher.