AdipoGen Life Sciences

IL-36Ra (human) Matched Pair Detection Set

Product Code:
 
AG-46B-0006
Product Group:
 
Antibody Pairs
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Enzyme-Linked Immunosorbent Assay (ELISA)
Shipping:
 
Blue Ice
Storage:
 
-20°C
 

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AG-46B-0006-KI011 Set£570.00
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This product comes from: Switzerland.
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Further Information

Alternate Names/Synonyms:
Interleukin-36 Receptor Antagonist Protein; IL-1F5; Interleukin-1 Family Member 5; IL-1delta Interleukin-1delta; Interleukin-1 Homolog 3; Interleukin-1-like Protein 1
Assay Type:
Sandwich
Detection Type:
Colorimetric
EClass:
32160000
Handling Advice:
Avoid freeze/thaw cycles.
Kit Contains:
1 vial standard protein (1µg) (lyophilized) [STD] | 1 vial coating antibody (270µl) [COAT] | 1 vial detection antibody (120µl) [DET] | 1 vial streptavidin-HRP (10µg) (lyophilized) [STREP]
Long Description:
Matched Pair Detection Set. Detects human IL-36Ra. Colorimetric assay. Sample Type: Cell Culture Supernatant. Range: 0.78 to 50ng/ml. Sensitivity: 0.5ng/ml. IL-36Ra/IL-1F5 is a highly and specific antagonist of the IL-1 receptor-related protein 2-mediated response to IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9). These cytokines bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. Recently mutations that affect the levels and the activity of IL-36Ra have been found in patients with pustular psoriasis, leading to enhanced production of inflammatory cytokines (IL-8 in particular) by keratinocytes.
NCBI, Uniprot Number:
Q9UHA7
Package Type:
Box
Product Description:
IL-36Ra/IL-1F5 is a highly and specific antagonist of the IL-1 receptor-related protein 2-mediated response to IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9). These cytokines bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. Recently mutations that affect the levels and the activity of IL-36Ra have been found in patients with pustular psoriasis, leading to enhanced production of inflammatory cytokines (IL-8 in particular) by keratinocytes.
Range:
0.78 to 50ng/ml
Sample Type:
Cell Culture Supernatant
Sensitivity:
0.5ng/ml
Specificity:
Detects human IL-36Ra.
Transportation:
Non-hazardous
UNSPSC Category:
ELISA Kits
UNSPSC Number:
41116126
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C.

References

Macrophage Phenotypes in Lung Fibrosis: C.K. Koss; Diss. Univ. Konstanz (2021)