AdipoGen Life Sciences

Tripolin A

Product Code:
 
AG-CR1-3520
Product Group:
 
Inhibitors and Activators
Regulatory Status:
 
RUO
Shipping:
 
-20°C
Storage:
 
-20°C
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Chemical Structure
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Chemical Structure

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AG-CR1-3520-M0011 mg£80.00
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AG-CR1-3520-M0055 mg£290.00
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Further Information

Alternate Names/Synonyms:
(3E)-3-[(2,5-Dihydroxyphenyl)methylene]-1,3-dihydro-2H-indol-2-one
Appearance:
Yellow solid.
CAS:
1148118-92-6
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Protect from light.
InChi:
InChI=1S/C15H11NO3/c17-10-5-6-14(18)9(7-10)8-12-11-3-1-2-4-13(11)16-15(12)19/h1-8,17-18H,(H,16,19)/b12-8-
InChiKey:
OMKSBDLWMROKNU-WQLSENKSSA-N
Long Description:
Chemical. CAS: 1148118-92-6. Formula: C15H11NO3. MW: 253.3. Specific non-ATP competitive Aurora A kinase inhibitor. Does not significantly inhibit Aurora B kinase in mammalian cells. Reduces localization of pAurora A on spindle microtubules (MTs), affects centrosome integrity, spindle formation and length and MT dynamics in interphase.
MDL:
MFCD22124085
Molecular Formula:
C15H11NO3
Molecular Weight:
253.3
Package Type:
Vial
Product Description:
Specific non-ATP competitive Aurora A kinase inhibitor [1]. Does not significantly inhibit Aurora B kinase in mammalian cells. Reduces localization of pAurora A on spindle microtubules (MTs), affects centrosome integrity, spindle formation and length and MT dynamics in interphase [1].
Purity:
>98% (HPLC, NMR)
SMILES:
OC1=CC=C(O)C(C=C2/C(=O)NC3=C2C=CC=C3)=C1
Solubility Chemicals:
Soluble in DMSO (at least 10 mg/ml).
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark.

References

Tripolin A, a novel small-molecule inhibitor of aurora A kinase, reveals new regulation of HURP's distribution on microtubules: I.A. Kesisova, et al.; PLoS One 8, e58485 (2013)