Zmp1 (M. tuberculosis) (rec.) (His)
Product Code:
AG-40T-0103
AG-40T-0103
Antibody Clonality:
Enzyme
Enzyme
Regulatory Status:
RUO
RUO
Shipping:
Dry Ice
Dry Ice
Storage:
-80°C
-80°C
No additional charges, what you see is what you pay! *
| Code | Size | Price |
|---|
| AG-40T-0103-C050 | 50 ug | £357.00 |
Quantity:
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This product comes from: Switzerland.
Typical lead time: 7-10 working days.
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Typical lead time: 7-10 working days.
Contact us for more accurate information.
- Further Information
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Further Information
Alternate Names/Synonyms:
Zinc Metalloprotease 1; Endopeptidase; Rv0198c
Biological Activity:
~0.5U/mg protein. Active towards the generic fluorogenic substrate for matrix metalloproteinases MMP2/MMP7 (Lit. 1).
Concentration:
0.5mg/ml (Lot specific)
EClass:
32160000
Endotoxin:
N/A
Form (Short):
liquid
Formulation:
Liquid. In 10mM TRIS-HCl, pH 8.0.
Handling Advice:
After opening, prepare aliquots and store at -80°C.Avoid freeze/thaw cycles.
Long Description:
Protein. Full-length Zmp1 (Mycobacterium tuberculosis) is fused at the N-terminus to a His-tag. Source: E. coli. Endotoxin content: N/A. Liquid. In 10mM TRIS-HCl, pH 8.0. Prefered cleavage sequence is PxxF. Purity: >98% (SDS-PAGE). M13 endopeptidases are single-pass, transmembrane zinc-metallopeptidases responsible in human for the regulation of the biological activity of many hormones and peptides and are involved in many important processes such as blood pressure regulation (Neprilysin or NEP1), cardiovascular development (Endothelin Converting Enzyme-1 or ECE-12), prevention of haemolytic reaction (KELL) and phosphate homeostasis (PHEX). Zmp1 is a soluble enzyme member of the M13 endopeptidases family that plays a key role in Mycobacterium tuberculosis pathogenicity with a still unknown mechanism. Recently, it was shown to suppress inflammasome activation by inhibiting caspase-1 activation, thus preventing processing of pro-IL-1beta into IL-1beta and the consequent phagosome maturation.
Molecular Weight:
~73.9kDa
NCBI, Uniprot Number:
O53649
Package Type:
Plastic Vial
Product Description:
M13 endopeptidases are single-pass, transmembrane zinc-metallopeptidases responsible in human for the regulation of the biological activity of many hormones and peptides and are involved in many important processes such as blood pressure regulation (Neprilysin or NEP1), cardiovascular development (Endothelin Converting Enzyme-1 or ECE-12), prevention of haemolytic reaction (KELL) and phosphate homeostasis (PHEX). Zmp1 is a soluble enzyme member of the M13 endopeptidases family that plays a key role in Mycobacterium tuberculosis pathogenicity with a still unknown mechanism. Recently, it was shown to suppress inflammasome activation by inhibiting caspase-1 activation, thus preventing processing of pro-IL-1beta into IL-1beta and the consequent phagosome maturation.
Purity:
>98% (SDS-PAGE)
Sequence:
Full-length Zmp1 (Mycobacterium tuberculosis) is fused at the N-terminus to a His-tag.
Source / Host:
E. coli
Specificity:
Prefered cleavage sequence is PxxF.
TAGs:
His
Transportation:
Non-hazardous
UNSPSC Category:
Other Enzymes
UNSPSC Number:
12352204
Use & Stability:
Stable for at least 6 months after receipt when stored at -80°C.
Documents
References
Crystal Structure of Mycobacterium tuberculosis Zinc-dependent Metalloprotease-1 (Zmp1), a Metalloprotease Involved in Pathogenicity: D.M. Ferraris, et al.; J. Biol. Chem. 286, 32475 (2011) | Functional characterization of the Mycobacterium tuberculosis zinc metallopeptidase Zmp1 and identification of potential substrates: A. Petrera, et al.; J. Biol. Chem. 393, 631 (2012)