Further Information
Alternate Names/Synonyms:
ICAM1; Intercellular Adhesion Molecule 1
Shows the biological function of the CD54 moiety and exerts a prolonged circulating half-life caused by the modified Fc domain.
32160000
<0.06EU/µg protein (LAL test; Lonza).
solid
Lyophilized from 0.2µm-filtered solution in PBS.
Avoid freeze/thaw cycles.Centrifuge lyophilized vial before opening and reconstitution.
Protein. The extracellular domain of mouse CD54 [ICAM-1] (aa 28-485) is fused to the N-terminus of the Fc region of a mutant mouse IgG2a. Source: CHO cells. Endotoxin content: <0.06EU/µg protein (LAL test; Lonza). Lyophilized from 0.2µm-filtered solution in PBS. Purity: >98% (SDS-PAGE). Intercellular Adhesion Molecule-1 (ICAM-1, CD54) binds the leukocyte integrins LFA-1 and Mac1. CD54 expression is weak on leukocytes, epithelial and resting endothelial cells, as well as some other cell types, but expression can be stimulated by IFN-gamma, TNF-alpha, IL-1beta and LPS. Soluble CD54 is found in a biologically active form in serum, probably as a result of proteolytic cleavage from the cell surface, and is elevated in patients with various inflammatory syndromes such as septic shock, LAD, cancer and transplantation.
AAH08626.1
Plastic Vial
Intercellular Adhesion Molecule-1 (ICAM-1, CD54) binds the leukocyte integrins LFA-1 and Mac1. CD54 expression is weak on leukocytes, epithelial and resting endothelial cells, as well as some other cell types, but expression can be stimulated by IFN-gamma, TNF-alpha, IL-1beta and LPS. Soluble CD54 is found in a biologically active form in serum, probably as a result of proteolytic cleavage from the cell surface, and is elevated in patients with various inflammatory syndromes such as septic shock, LAD, cancer and transplantation.
>98% (SDS-PAGE)
The extracellular domain of mouse CD54 [ICAM-1] (aa 28-485) is fused to the N-terminus of the Fc region of a mutant mouse IgG2a.
CHO cells
Fc
Non-hazardous
Other Proteins
12352202
Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.