Aureothin

The structure of aureothin, a nitro compound obtained from Streptomyces thioluteus: Y. Hirata, et al.; Tetrahedron 14, 252 (1961) | Identification of mycolutein and pulvomycin as aureothin and labilomycin respectively: J.L. Schwartz, et al.; J. Antibiot. 29, 236 (1976) | Two binding sites of inhibitors in NADH: ubiquinone oxidoreductase (complex I). Relationship of one site with the ubiquinone-binding site of bacterial glucose:ubiquinone oxidoreductase: T. Friedrich, et al.; Eur. J. Biochem. 219, 691 (1994) | Absolute configuration of (+)-aureothin: A toxic Metabolite posessing gamma-pyrone unit: Y. Ishibashi, et al.; Bull. Chem. Soc. Jpn. 68, 3643 (1995) | Gamma-pyrone compounds with selective and potent anti-Helicobacter pylori activity: M. Taniguchi, et al.; J. Antibiot. 53, 844 (2000) | Dissection of the late steps in aureothin biosynthesis: M. M?ller, et al.; ChemBioChem 7, 37 (2006) | New aureothin derivative, alloaureothin, from Streptomyces sp. MM23: J.Y. Ueda, et al.; J. Antibiot. 60, 321 (2007) | Chemoenzymatic total synthesis of the antiproliferative polyketide (+)-(R)-aureothin: M. Werneburg & C. Hertweck; Chembiochem 9, 2064 (2008) | Selective and potent in vitro antitrypanosomal activities of ten microbial metabolites: K. Otoguro, et al.; J. Antibiot. 61, 372 (2008) | Natural lipophilic inhibitors of mitochondrial complex I are candidate toxins for sporadic neurodegenerative tau pathologies: M. H?llerhagen, et al.; Exp. Neurol. 220, 133 (2009) | Evolution of metabolic diversity in polyketide-derived pyrones: using the non-colinear Aureothin assembly line as a model system: B. Busch, et al.; Phytochemistry 70, 1833 (2009) | Exploiting enzymatic promiscuity to engineer a focused library of highly selective antifungal and antiproliferative Aureothin analogues: M. Werneburg, et al.; J. Am. Chem. Soc. 132, 10407 (2010) | Potent inhibition of HIV replication in primary human cells by novel synthetic polyketides inspired by Aureothin: A. Herrmann, et al.; Sci. Rep. 10, 1326 (2020)