Becatecarin
Product Code:
BVT-0258
BVT-0258
Regulatory Status:
RUO
RUO
Shipping:
20°C
20°C
Storage:
-20°C
-20°C
No additional charges, what you see is what you pay! *
| Code | Size | Price |
|---|
| BVT-0258-C250 | 250 ug | £190.00 |
Quantity:
| BVT-0258-M001 | 1 mg | £535.00 |
Quantity:
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This product comes from: Switzerland.
Typical lead time: 10-14 working days.
Contact us for more accurate information.
Typical lead time: 10-14 working days.
Contact us for more accurate information.
- Further Information
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- References
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Further Information
Alternate Names/Synonyms:
6-N-[2-(Diethylamino)ethyl]rebeccamycin; NSC 655649; BMY-27557-14; BMS-181176; XL119
Appearance:
Yellow solid.
CAS:
119673-08-4
Class:
6.1
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS06
Hazards:
H301, H311, H319, H332
InChi:
InChI=1S/C33H34Cl2N4O7/c1-4-37(5-2)12-13-38-31(43)22-20-15-8-6-10-17(34)24(15)36-25(20)27-21(23(22)32(38)44)16-9-7-11-18(35)26(16)39(27)33-29(42)28(41)30(45-3)19(14-40)46-33/h6-11,19,28-30,33,36,40-42H,4-5,12-14H2,1-3H3/t19-,28-,29-,30-,33-/m1/s1
InChiKey:
JSKFWUPVIZYJMR-UDOAKELVSA-N
Long Description:
Chemical. CAS: 119673-08-4. Formula: C33H34Cl2N4O7. MW: 669.6. Semisynthetic. Antibiotic. Semisynthetic water-soluble derivative of rebeccamycin (Prod. No. BVT-0139). Antitumor compound. Topoisomerase II (Topo II) inhibitor. DNA intercalating agent.
MDL:
MFCD14635404
Molecular Formula:
C33H34Cl2N4O7
Molecular Weight:
669.6
Package Type:
Plastic Vial
PG:
III
Precautions:
P261, P280, P301, P310, P302, P352, P312, P405
Product Description:
Antibiotic. Semisynthetic water-soluble derivative of rebeccamycin (Prod. No. BVT-0139). Antitumor compound. Topoisomerase II (Topo II) inhibitor. DNA intercalating agent.
Purity:
>98% (HPLC)
Signal word:
Danger
SMILES:
CCN(CC)CCN1C(=O)C2=C3C(NC4=C3C=CC=C4Cl)=C3N(C4OC(CO)C(OC)C(O)C4O)C4=C(C=CC=C4Cl)C3=C2C1=O
Solubility Chemicals:
Soluble in DMSO or water (pH dependent).
Source / Host:
Semisynthetic.
Transportation:
Excepted Quantity
UN Nummer:
UN 3462
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C. After reconstitution protect from light at -20°C.
Documents
References
Water soluble derivatives of rebeccamycin: T. Kaneko, et al.; J. Antibiot. 43, 125 (1990) | Discovery of antitumor indolocarbazoles: rebeccamycin, NSC 655649, and fluoroindolocarbazoles: B.H. Long, et al.; Curr. Med. Chem. Anticancer Agents 2, 255 (2002) | Becatecarin (Helsinn Healthcare): G.W. Rewcastle; IDrugs 8, 838 (2005) (Review) | Phase I and pharmacokinetic study of sequences of the rebeccamycin analogue NSC 655649 and cisplatin in patients with advanced solid tumors: A.D. Ricart, et al.; Clin. Cancer Res. 11, 8728 (2005) | A phase II trial of rebeccamycin analogue (NSC #655649) in children with solid tumors: a children`s oncology group study: A.-M. Langevin, et al.; Pediatr. Blood Cancer 50, 577 (2008) | Becatecarin (rebeccamycin analog, NSC 655649) is a transport substrate and induces expression of the ATP-binding cassette transporter, ABCG2, in lung carcinoma cells: R. W. Robey, et al.; Cancer Chemother. Pharmacol. 64, 575 (2009)