Further Information
Alternate Names/Synonyms:
(-)-TAN 2162
Yellow powder.
183202-73-5
32160000
liquid
GHS07
Protect from light.
H302, H312, H319
InChI=1S/C29H42O6/c1-14-8-9-22-18(5)24(30)19(6)28(34-22)23-21-13-29(33,17(4)12-16(3)11-15(2)10-14)35-27(21)20(7)25(31)26(23)32/h10,13-14,16-19,22,24,28,30,32-33H,8-9,11-12H2,1-7H3/b15-10+/t14-,16+,17-,18-,19+,22+,24-,28+,29+/m0/s1
HKLDUJXJTQJSEJ-OLXNOMCWSA-N
Chemical. CAS: 183202-73-5. Formula: C29H42O6. MW: 486.6. Isolated from Streptomyces violaceoruber. Antibiotic. Potent endothelin receptor antagonist. Anti-osteoporotic. Antibacterial. Cytotoxic. Mediates its cytotoxic effects, at least in part, through proteasome inhibition.
MFCD14635192
C29H42O6
486.6
Plastic Vial
P270, P280, P301, P312, P302, P352, P312
Antibiotic. Potent endothelin receptor antagonist. Anti-osteoporotic. Antibacterial. Anticancer agent. Cytotoxic against several carcinoma cell lines (GI50<100nM). 20S proteasome inhibitor. Induces apoptosis by inhibition of chymotrypsin-like proteasome activity.
>98% (HPLC)
Warning
[H][C@]12CC[C@H](C)C=C(C)C[C@@H](C)C[C@H](C)[C@]3(O)OC4=C(C)C(=O)C(O)=C(C4=C3)[C@]([H])(O1)[C@H](C)[C@@H](O)[C@H]2C
Slightly soluble in methanol or DMSO.
Isolated from Streptomyces violaceoruber.
Non-hazardous
Natural Products/Extracts
12352200
Stable for at least 1 year after receipt when stored at -20°C. After reconstitution protect from light at -20°C.