AdipoGen Life Sciences

CD40 (human):Fc (human) (rec) (MultiPack)

Product Code:
 
AG-40B-0083
Product Group:
 
Recombinant Proteins
Host Type:
 
Human
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
Shipping:
 
Blue Ice
Storage:
 
-20°C
 

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CodeSizePrice
AG-40B-0083-C05050 ug£220.00
Quantity:
AG-40B-0083-30503 x 50 ug£430.00
Quantity:
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This product comes from: Switzerland.
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Further Information

Alternate Names/Synonyms:
Tumor Necrosis Factor Receptor Superfamily Member 5; TNFRSF5; CD40L Receptor
Biological Activity:
Blocks the binding of CD40L to CD40.
Concentration:
1mg/ml after reconstitution.
EClass:
32160000
Endotoxin:
<0.01EU/µg purified protein (LAL test; Lonza).
Form (Short):
liquid
Formulation:
Lyophilized. Contains PBS.
Handling Advice:
After reconstitution, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.Centrifuge lyophilized vial before opening and reconstitution.PBS containing at least 0.1% BSA should be used for further dilutions.
Long Description:
Protein. The Fc portion of human IgG1 is fused to the C-terminus of human CD40 (aa 21-193). Source: HEK 293 cells. Endotoxin content: <0.01EU/µg purified protein (LAL test; Lonza). Lyophilized. Contains PBS. Binds human and mouse CD40L. Purity: >95% (SDS-PAGE). CD40 belongs to the TNF-receptor superfamily and is essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development and germinal center formation. The interaction of CD40-CD40L is necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B cells and macrophages. Consistent with its widespread expression on normal cells, CD40 is also expressed on a wide range of tumor cells, including non-Hodgkin's and Hodgkin's lymphomas, myeloma and some carcinomas including nasopharynx, bladder, cervix, kidney and ovary.
Molecular Weight:
~54kDa (SDS-PAGE)
NCBI, Uniprot Number:
P25942
Package Type:
Plastic Vial
Product Description:
CD40 belongs to the TNF-receptor superfamily and is essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development and germinal center formation. The interaction of CD40-CD40L is necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B cells and macrophages. Consistent with its widespread expression on normal cells, CD40 is also expressed on a wide range of tumor cells, including non-Hodgkin's and Hodgkin's lymphomas, myeloma and some carcinomas including nasopharynx, bladder, cervix, kidney and ovary.
Purity:
>95% (SDS-PAGE)
Sequence:
The Fc portion of human IgG1 is fused to the C-terminus of human CD40 (aa 21-193).
Source / Host:
HEK 293 cells
Specificity:
Binds human and mouse CD40L.
TAGs:
Fc
Transportation:
Non-hazardous
UNSPSC Category:
Other Proteins
UNSPSC Number:
12352202
Use & Stability:
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.