AdipoGen Life Sciences

Fas (human):Fc (human) (rec.) (MultiPack)

Product Code:
 
AG-40B-0082
Product Group:
 
Recombinant Proteins
Host Type:
 
Human
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
Shipping:
 
Blue Ice
Storage:
 
-20°C
 

No additional charges, what you see is what you pay! *

CodeSizePrice
AG-40B-0082-C05050 ug£230.00
Quantity:
AG-40B-0082-30503 x 50 ug£450.00
Quantity:
Prices exclude any Taxes / VAT
How to order with us   Contact us
Stay in control of your spending. These prices have no additional charges, not even shipping!
* Rare exceptions are clearly labelled (only 0.14% of items!).
Multibuy discounts available! Contact us to find what you can save.
This product comes from: Switzerland.
Typical lead time: 7-10 working days.
Contact us for more accurate information.
  • Further Information
  • Documents
  • References
  • Related Products
  • Show All

Further Information

Alternate Names/Synonyms:
Tumor Necrosis Factor Receptor Superfamily Member 6; TNFRSF6; Apo-1 Antigen; CD95
Biological Activity:
Blocks the binding of FasL to Fas.
Concentration:
1mg/ml after reconstitution.
EClass:
32160000
Endotoxin:
<0.01EU/µg purified protein (LAL test; Lonza).
Form (Short):
liquid
Formulation:
Lyophilized. Contains PBS.
Handling Advice:
After reconstitution, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.Centrifuge lyophilized vial before opening and reconstitution.PBS containing at least 0.1% BSA should be used for further dilutions.
Long Description:
Protein. The Fc portion of human IgG1 is fused to the C-terminus of human Fas (aa 26-170). Source: HEK 293 cells. Endotoxin content: <0.01EU/µg purified protein (LAL test; Lonza). Lyophilized. Contains PBS. Binds human and mouse FasL. Purity: >95% (SDS-PAGE). FasL is a cytokine that binds to Fas/TNFRSF6, a receptor that transduces the apoptotic signal into cells. FasL is involved in cytotoxic T cell mediated apoptosis and in T cell development.
Molecular Weight:
~47kDa (SDS-PAGE).
NCBI, Uniprot Number:
P25445
Package Type:
Plastic Vial
Product Description:
FasL is a cytokine that binds to Fas/TNFRSF6, a receptor that transduces the apoptotic signal into cells. FasL is involved in cytotoxic T cell mediated apoptosis and in T cell development.
Purity:
>95% (SDS-PAGE)
Sequence:
The Fc portion of human IgG1 is fused to the C-terminus of human Fas (aa 26-170).
Source / Host:
HEK 293 cells
Specificity:
Binds human FasL with an ED50 of <5ng/ml. Binds mouse FasL.
TAGs:
Fc
Transportation:
Non-hazardous
UNSPSC Category:
Other Proteins
UNSPSC Number:
12352202
Use & Stability:
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

References

Decitabine treatment of glioma-initiating cells enhances immune recognition and killing: C. Riccadonna, et al.; PLOS One 11, e0162105 (2016) | CART cells are prone to Fas- and DR5-mediated cell death: B.O. Tschumi, et al.; J. ImmunoTherapy Cancer 6, 71 (2018)