AdipoGen Life Sciences

FGF-21 (human):Fc (human) (rec.)

Product Code:
 
AG-40A-0095
Product Group:
 
Recombinant Proteins
Host Type:
 
Human
Regulatory Status:
 
RUO
Target Species:
 
Human
Shipping:
 
Blue Ice
Storage:
 
-20°C
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ERK and FRS2alpha phosphorylation induced by FGF-21 in bKlotho expressing cells. bKlotho expressing cells were serum starved for 16hr and then stimulated with hFGF-21-His (competitor), FGF-21-Fc (Prod. No. AG-40A-0095), mCD137-Fc (Fc control) and
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ERK and FRS2alpha phosphorylation induced by FGF-21 in bKlotho expressing cells. bKlotho expressing cells were serum starved for 16hr and then stimulated with hFGF-21-His (competitor), FGF-21-Fc (Prod. No. AG-40A-0095), mCD137-Fc (Fc control) and

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AG-40A-0095-C01010 ug£160.00
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AG-40A-0095-C05050 ug£330.00
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Further Information

Alternate Names/Synonyms:
Fibroblast Growth Factor 21
Biological Activity:
Activates ERK and FRS2alpha phosphorylation in bKlotho expressing cells.
Concentration:
~1mg/ml
EClass:
32160000
Endotoxin:
<0.1EU/µg purified protein (LAL test; Lonza).
Form (Short):
liquid
Formulation:
Liquid. 0.2µm-filtered solution in PBS.
Handling Advice:
After opening, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.For maximum product recovery after thawing, centrifuge the vial before opening the cap.
Long Description:
Protein. Human FGF-21 (aa 1-209) is fused at the C-terminus to the Fc portion of human IgG1. Source: HEK 293 cells. Endotoxin content: <0.1EU/µg purified protein (LAL test; Lonza). Liquid. 0.2µm-filtered solution in PBS. Purity: >95% (SDS-PAGE). FGF-21 (Fibroblast growth factor 21) stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of betaKlotho.
Molecular Weight:
~50kDa (SDS-PAGE)
NCBI, Uniprot Number:
Q9NSA1
Package Type:
Plastic Vial
Product Description:
FGF-21 (Fibroblast growth factor 21) stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of betaKlotho.
Purity:
>95% (SDS-PAGE)
Sequence:
Human FGF-21 (aa 1-209) is fused at the C-terminus to the Fc portion of human IgG1.
Source / Host:
HEK 293 cells
TAGs:
Fc
Transportation:
Non-hazardous
UNSPSC Category:
Other Proteins
UNSPSC Number:
12352202
Use & Stability:
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.