GITRL Soluble (mouse) (rec.)
Product Code:
AG-40A-0008
AG-40A-0008
Host Type:
Human
Human
Regulatory Status:
RUO
RUO
Target Species:
Mouse
Mouse
Shipping:
Blue Ice
Blue Ice
Storage:
-20°C
-20°C
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Code | Size | Price |
---|
AG-40A-0008-C050 | 50 ug | £260.00 |
Quantity:
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This product comes from: Switzerland.
Typical lead time: 7-10 working days.
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Typical lead time: 7-10 working days.
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Further Information
Alternate Names/Synonyms:
Glucocorticoid-induced TNF Receptor Ligand; AITRL; Activation-inducible TNF-related Ligand; TNFSF18
Biological Activity:
Induces GITR-mediated NF-kappaB activation in HEK 293 cells.
Concentration:
0.5mg/ml
EClass:
32160000
Endotoxin:
<0.1EU/µg purified protein (LAL test; Lonza).
Form (Short):
liquid
Formulation:
Liquid. 0.2µm-filtered solution in 10mM glycine, pH 10.0.
Handling Advice:
After opening, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.For maximum product recovery after thawing, centrifuge the vial before opening the cap.
Long Description:
Protein. The extracellular domain of mouse GITRL (aa 45-173) is fused at the N-terminus to a FLAG®-tag. Source: HEK 293 cells. Endotoxin content: <0.1EU/µg purified protein (LAL test; Lonza). Liquid. 0.2µm-filtered solution in 10mM glycine, pH 10.0. Binds to mouse GITR. Purity: >90% (SDS-PAGE). GITRL (Glucocorticoid-induced TNF receptor ligand) is expressed on dendritic cells (DC), monocytes, macrophages, B cells, activated T cells, endothelial cells, osteoclasts and various healthy non-lymphoid tissues (e.g. testis). GITRL is constitutively expressed and released as soluble form by solid tumors and various hematopoietic malignancies. GITRL causes differentiation of osteoclasts, activation of macrophages, but also alteration of carcinoma and leukemia cells and influences apoptosis. Binding to GITR is important in regulating T cell proliferation and TCR-mediated apoptosis. GITRL is implicated in development of autoimmune diseases and in the immune response against infectious pathogens and tumors.
Molecular Weight:
~22kDa (SDS-PAGE)
NCBI, Uniprot Number:
Q7TS55
Package Type:
Plastic Vial
Product Description:
GITRL (Glucocorticoid-induced TNF receptor ligand) is expressed on dendritic cells (DC), monocytes, macrophages, B cells, activated T cells, endothelial cells, osteoclasts and various healthy non-lymphoid tissues (e.g. testis). GITRL is constitutively expressed and released as soluble form by solid tumors and various hematopoietic malignancies. GITRL causes differentiation of osteoclasts, activation of macrophages, but also alteration of carcinoma and leukemia cells and influences apoptosis. Binding to GITR is important in regulating T cell proliferation and TCR-mediated apoptosis. GITRL is implicated in development of autoimmune diseases and in the immune response against infectious pathogens and tumors.
Purity:
>90% (SDS-PAGE)
Sequence:
The extracellular domain of mouse GITRL (aa 45-173) is fused at the N-terminus to a FLAG®-tag.
Source / Host:
HEK 293 cells
Specificity:
Binds to mouse GITR.
TAGs:
FLAG
Transportation:
Non-hazardous
UNSPSC Category:
Other Proteins
UNSPSC Number:
12352202
Use & Stability:
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
References
Identification of a ligand for glucocorticoid-induced tumor necrosis factor receptor constitutively expressed in dendritic cells: K.Y. Yu, et al.; BBRC 310, 433 (2003)