TargetMol

PNU-145156E (FCE26644)

Product Code:
 
TAR-TP2468
Product Group:
 
Peptides
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
PNU-145156E (FCE26644) a novel angiogenesis inhibitor, has been shown to block circulating angiogenesis promoting growth factor in animal studies and has shown anti-tumor effects in solid tumors in mice.
CAS:
154788-16-6
Molecular Weight:
1213.07
Purity:
0.98
SMILES:
[Na].[Na].[Na].[Na].Cn1cc(NC(=O)Nc2cc(C(=O)Nc3cc(C(=O)Nc4ccc5cc(cc(c5c4)S(O)(=O)=O)S(O)(=O)=O)n(C)c3)n(C)c2)cc1C(=O)Nc1cc(C(=O)Nc2ccc3cc(cc(c3c2)S(O)(=O)=O)S(O)(=O)=O)n(C)c1

References

Groen HJ, de Vries EG, Wynendaele W, van der Graaf WT, Fokkema E, Lechuga MJ, Poggesi I, Dirix LY, van Oosterom AT. PNU-145156E, a novel angiogenesis inhibitor, in patients with solid tumors: a phase I and pharmacokinetic study. Clin Cancer Res. 2001 Dec;7(12):3928-33. PubMed PMID: 11751484. Zamai M, Hariharan C, Pines D, Safran M, Yayon A, Caiolfa VR, Cohen-Luria R, Pines E, Parola AH. Nature of Interaction between basic fibroblast growth factor and the antiangiogenic drug 7,7-(carbonyl-bis[imino-N-methyl-4,2-pyrrolecarbonylimino[N-methyl-4,2-pyrrole]-c arbonylimino])-bis-(1,3-naphtalene disulfonate). II. Removal of polar interactions affects protein folding. Biophys J. 2002 May;82(5):2652-64. PubMed PMID: 11964252; PubMed Central PMCID: PMC1302054. Dhar S, Gullbo J, Csoka K, Eriksson E, Nilsson K, Nickel P, Larsson R, Nygren P. Antitumour activity of suramin analogues in human tumour cell lines and primary cultures of tumour cells from patients. Eur J Cancer. 2000 Apr;36(6):803-9. PubMed PMID: 10762755. Possati L, Campioni D, Sola F, Leone L, Ferrante L, Trabanelli C, Ciomei M, Montesi M, Rocchetti R, Talevi S, Bompadre S, Caputo A, Barbanti-Brodano G, Corallini A. Antiangiogenic, antitumoural and antimetastatic effects of two distamycin A derivatives with anti-HIV-1 Tat activity in a Kaposi's sarcoma-like murine model. Clin Exp Metastasis. 1999;17(7):575-82. PubMed PMID: 10845556.