TargetMol

Spantide II

Product Code:
 
TAR-TP2353
Product Group:
 
Peptides
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
Spantide II is an antagonist of tachykinin.
CAS:
129176-97-2
Molecular Weight:
1668.77
Purity:
0.98
SMILES:
C([C@H](C(N[C@H](C(N[C@H](CC=1C=2C(NC1)=CC=CC2)C(N[C@H](C(N[C@@H](CCCC)C(N)=O)=O)CC(C)C)=O)=O)CC3=CC=CC=C3)=O)NC([C@@H](NC([C@@H](CC4=CC(Cl)=C(Cl)C=C4)NC(=O)[C@H]5N(C([C@@H](NC(=O)[C@H]6N(C([C@@H](CCCCNC(=O)C=7C=CC=NC7)N)=O)CCC6)CC=8C=CC=NC8)=O)CCC5)=O)CC(N)=O)=O)C=9C=%10C(NC9)=CC=CC%10

References

H?kanson R, Leander S, Asano N, Feng DM, Folkers K. Spantide II, a novel tachykinin antagonist having high potency and low histamine-releasing effect. Regul Pept. 1990 Oct 29;31(1):75-82. PubMed PMID: 1702895. Wiesenfeld-Hallin Z, Xu XJ, Kristensson K, H?kanson R, Feng DM, Folkers K. Antinociceptive and substance P antagonistic effects of intrathecally injected spantide II in rat: no signs of motor impairment or neurotoxicity. Regul Pept. 1990 Jun;29(1):1-11. PubMed PMID: 1697080. Shah PP, Desai PR, Singh M. Effect of oleic acid modified polymeric bilayered nanoparticles on percutaneous delivery of spantide II and ketoprofen. J Control Release. 2012 Mar 10;158(2):336-45. doi: 10.1016/j.jconrel.2011.11.016. Epub 2011 Nov 21. PubMed PMID: 22134117; PubMed Central PMCID: PMC3294128. Kikwai L, Babu RJ, Kanikkannan N, Singh M. Stability and degradation profiles of Spantide II in aqueous solutions. Eur J Pharm Sci. 2006 Feb;27(2-3):158-66. Epub 2005 Nov 2. PubMed PMID: 16266798.