TAK-683

Product Code:

TAR-TP2156L

Product Group:

Peptides

Supplier:

TargetMol

Regulatory Status:

RUO

Shipping:

cool pack

Storage:

-20°C

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Code	Size	Price

TAR-TP2156L-100mg

100mg

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TAR-TP2156L-500mg

500mg

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Further Information

Bioactivity:

TAK-683 is an effective full KISS1 receptor agonist (IC50=170 pM). TAK-683 is a nonapeptide metastin analog, shows agonistic activities to KISS1R (EC50: 0.96 nM and 1.6 nM for human and rat, respectively).

CAS:

872719-49-8

Molecular Weight:

1298.45

Purity:

0.98

SMILES:

C([C@@H](NC([C@@H](CC1=CC=C(O)C=C1)NC(C)=O)=O)C(N[C@H](C(N[C@H](C(N[C@@H](CC2=CC=CC=C2)C(NNC(N[C@H](C(N[C@H](C(N[C@@H](CC=3C=4C(NC3)=CC=CC4)C(N)=O)=O)CCCNC(NC)=N)=O)CC(C)C)=O)=O)=O)[C@@H](C)O)=O)CC(N)=O)=O)C=5C=6C(NC5)=CC=CC6

Documents

References

Hisanori MATSUI, et al. Functional Analyses of Kisspeptin in Controlling Gonadal Functions Nishizawa N, et al. Design and Synthesis of an Investigational Nonapeptide KISS1 Receptor (KISS1R) Agonist, Ac-d-Tyr-Hydroxyproline (Hyp)-Asn-Thr-Phe-azaGly-Leu-Arg(Me)-Trp-NH2 (TAK-448), with Highly Potent Testosterone-Suppressive Activity and Excellent Water Solubility. J Med Chem. 2016 Oct 13;59(19):8804-8811. Epub 2016 Sep 21. Asami T, et al.Design, synthesis, and biological evaluation of novel investigational nonapeptide KISS1R agonists with testosterone-suppressive activity.J Med Chem. 2013 Nov 14;56(21):8298-307. Matsui H, et al. Pharmacologic?profiles?of?investigational?kisspeptin/metastin?analogues,?TAK-448?and?TAK-683, in?adult?male?rats?in?comparison?to the?GnRH?analogue?leuprolide.Eur J Pharmacol.?2014 Jul 15;735:77-85.