TargetMol

TAK-683 TFA (872719-49-8 free base)

Product Code:
 
TAR-TP2156
Product Group:
 
Peptides
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
 

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TAR-TP2156-100mg100mgEnquire
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TAR-TP2156-500mg500mgEnquire
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Further Information

Bioactivity:
TAK-683 TFA is a potent full agonist of the KISS1 receptor (KISS1R; IC50: 170 pM) with improved metabolic stability. It shows agonistic activities to KISS1R (EC50s: 0.96 nM and 1.6 nM for human and rat).
CAS:
TP2156
Molecular Weight:
1412.47
Purity:
0.98

References

Nishizawa N, et al. Design and Synthesis of an Investigational Nonapeptide KISS1 Receptor (KISS1R) Agonist, Ac-d-Tyr-Hydroxyproline (Hyp)-Asn-Thr-Phe-azaGly-Leu-Arg(Me)-Trp-NH2 (TAK-448), with Highly Potent Testosterone-Suppressive Activity and Excellent Water Solubility. J Med Chem. 2016 Oct 13;59(19):8804-8811. Epub 2016 Sep 21. Tanaka A, et al. Evaluation of pharmacokinetics/pharmacodynamics and efficacy of one-month depots of TAK-448 and?TAK-683, investigational kisspeptin analogs, in male rats and an androgen-dependent prostate cancer model.Eur J Pharmacol.?2018 Mar 5;822:138-146. Asami T, et al.Design, synthesis, and biological evaluation of novel investigational nonapeptide KISS1R agonists with testosterone-suppressive activity.J Med Chem. 2013 Nov 14;56(21):8298-307. Matsui H, et al. Pharmacologic?profiles?of?investigational?kisspeptin/metastin?analogues,?TAK-448?and?TAK-683, in?adult?male?rats?in?comparison?to the?GnRH?analogue?leuprolide.Eur J Pharmacol.?2014 Jul 15;735:77-85.