TargetMol

Atrovastatin-PEG3-FITC

Product Code:
 
TAR-T38920
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
Atrovastatin-PEG3-FITC (compound S31) functions as a ligand in fluorescence anisotropy assay. Its primary role is as a KRAS-PDEδ interaction inhibitor.
CAS:
1440755-31-6
Molecular Weight:
1150.33
Purity:
0.98
SMILES:
CC(C)c1c(C(=O)Nc2ccccc2)c(c(-c2ccc(F)cc2)n1CC[C@@H](O)C[C@@H](O)CC(=O)NCCCOCCOCCOCCCNC(=S)Nc1ccc2c(c1)C(=O)OC21c2ccc(O)cc2Oc2cc(O)ccc12)-c1ccccc1

References

Gunther Zimmermann, et al. Small molecule inhibition of the KRAS-PDE? interaction impairs oncogenic KRAS signaling. Nature. 2013 May 30;497(7451):638-42. Yan Jiang, et al. Structural Biology-Inspired Discovery of Novel KRAS-PDE? Inhibitors. J Med Chem. 2017 Nov 22;60(22):9400-9406.