TargetMol

Sceptrin

Product Code:
 
TAR-T34564
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
Sceptrin is a pyrrole-imidazole alkaloid that is naturally produced by various marine sponges.
CAS:
79703-25-6
Molecular Weight:
693.22
Purity:
0.98
SMILES:
O=C(C1=CC(Br)=CN1)NC[C@H]2[C@H](C3=CN=C(N3)N)[C@@H](C4=CN=C(N4)N)[C@@H]2CNC(C5=CC(Br)=CN5)=O.Cl.Cl

References

Cipres A, O'Malley DP, Li K, Finlay D, Baran PS, Vuori K. Sceptrin, a marine natural compound, inhibits cell motility in a variety of cancer cell lines. ACS Chem Biol. 2010 Feb 19;5(2):195-202. doi: 10.1021/cb900240k. PubMed PMID: 20030414; PubMed Central PMCID: PMC2825093. Ma Z, Wang X, Wang X, Rodriguez RA, Moore CE, Gao S, Tan X, Ma Y, Rheingold AL, Baran PS, Chen C. ORGANIC SYNTHESIS. Response to Comment on "Asymmetric syntheses of sceptrin and massadine and evidence for biosynthetic enantiodivergence". Science. 2015 Jul 10;349(6244):149. doi: 10.1126/science.aaa9626. Epub 2015 Jul 9. PubMed PMID: 26160939; PubMed Central PMCID: PMC4536548. Ma Z, Wang X, Wang X, Rodriguez RA, Moore CE, Gao S, Tan X, Ma Y, Rheingold AL, Baran PS, Chen C. Asymmetric syntheses of sceptrin and massadine and evidence for biosynthetic enantiodivergence. Science. 2014 Oct 10;346(6206):219-24. doi: 10.1126/science.1255677. PubMed PMID: 25301624; PubMed Central PMCID: PMC4205478. Sherman DH, Tsukamoto S, Williams RM. ORGANIC SYNTHESIS. Comment on "Asymmetric syntheses of sceptrin and massadine and evidence for biosynthetic enantiodivergence". Science. 2015 Jul 10;349(6244):149. doi: 10.1126/science.aaa9349. Epub 2015 Jul 9. PubMed PMID: 26160938; PubMed Central PMCID: PMC4499860.