TargetMol

LASSBio-881

Product Code:
 
TAR-T32582
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-T32582-500mg500mgEnquire
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Further Information

Bioactivity:
LASSBio-881 is a non-selective partial agonist of the CB1 and CB2 cannabinoid receptors, as well as an antagonist of the TRPV1 receptor.
CAS:
T32582
Molecular Weight:
441.48
Purity:
0.98
SMILES:
O=C(C1=C([N+]([O-])=O)C=C(OCO2)C2=C1)NN/C=C3C=C(C(C)(C)C)C(C(C(C)(C)C)=C/3)=O

References

Salat K, Moniczewski A, Librowski T. Nitrogen, oxygen or sulfur containing heterocyclic compounds as analgesic drugs used as modulators of the nitroxidative stress. Mini Rev Med Chem. 2013 Mar;13(3):335-52. Review. PubMed PMID: 22876956. Duarte CD, Tributino JL, Lacerda DI, Martins MV, Alexandre-Moreira MS, Dutra F, Bechara EJ, De-Paula FS, Goulart MO, Ferreira J, Calixto JB, Nunes MP, Bertho AL, Miranda AL, Barreiro EJ, Fraga CA. Synthesis, pharmacological evaluation and electrochemical studies of novel 6-nitro-3,4-methylenedioxyphenyl-N-acylhydrazone derivatives: Discovery of LASSBio-881, a new ligand of cannabinoid receptors. Bioorg Med Chem. 2007 Mar 15;15(6):2421-33. Epub 2007 Jan 17. PubMed PMID: 17275312. Tributino JL, Santos ML, Mesquita CM, Lima CK, Silva LL, Maia RC, Duarte CD, Barreiro EJ, Fraga CA, Castro NG, Miranda AL, Guimaraes MZ. LASSBio-881: an N-acylhydrazone transient receptor potential vanilloid subfamily type 1 antagonist orally effective against the hypernociception induced by capsaicin or partial sciatic ligation. Br J Pharmacol. 2010 Apr;159(8):1716-23. PubMed PMID: 20401963; PubMed Central PMCID: PMC2925494.