TargetMol

RXP-407

Product Code:
 
TAR-T28632
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
RXP 407 is a selective inhibitor of the N-domain of angiotensin I-converting enzyme. RXP 407 blocks the degradation of hemoregulatory peptide acetyl-Ser-Asp-Lys-Pro with no effect on angiotensin I hydrolysis in vivo.
CAS:
237770-41-1
Molecular Weight:
498.47
Purity:
0.98
SMILES:
[C@@H](CC1=CC=CC=C1)(NC([C@H](CC(O)=O)NC(C)=O)=O)P(C[C@H](C(N[C@H](C(N)=O)C)=O)C)(=O)O

References

Junot C, Gonzales MF, Ezan E, Cotton J, Vazeux G, Michaud A, Azizi M, Vassiliou S, Yiotakis A, Corvol P, Dive V. RXP 407, a selective inhibitor of the N-domain of angiotensin I-converting enzyme, blocks in vivo the degradation of hemoregulatory peptide acetyl-Ser-Asp-Lys-Pro with no effect on angiotensin I hydrolysis. J Pharmacol Exp Ther. 2001 May;297(2):606-11. PubMed PMID: 11303049. Dive V, Cotton J, Yiotakis A, Michaud A, Vassiliou S, Jiracek J, Vazeux G, Chauvet MT, Cuniasse P, Corvol P. RXP 407, a phosphinic peptide, is a potent inhibitor of angiotensin I converting enzyme able to differentiate between its two active sites. Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4330-5. PubMed PMID: 10200262; PubMed Central PMCID: PMC16332.