TargetMol

Voxvoganan

Product Code:
 
TAR-T27964
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-T27964-100mg100mgEnquire
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TAR-T27964-500mg500mgEnquire
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Further Information

Bioactivity:
Lytixar is a Synthetic Antimicrobial Peptide, it shows activity against Daptomycin-Nonsusceptible, Methicillin-Resistant, Vancomycin-Intermediate, Vancomycin-Resistant, and Linezolid-Nonsusceptible Staphylococcus aureus. LTX-109 demonstrated a MIC range of 2 to 4 ug/ml and dose-dependent rapid bactericidal activity against S. aureus. This activity was not influenced by resistance to other antistaphylococcal agents.
CAS:
1166254-80-3
Molecular Weight:
788.08
Purity:
0.98
SMILES:
C([C@@H](C(N[C@H](C(NCCC1=CC=CC=C1)=O)CCCNC(=N)N)=O)NC([C@H](CCCNC(=N)N)N)=O)C=2C=3C(=C(C(C)(C)C)C=C(C(C)(C)C)C3)NC2C(C)(C)C

References

Isaksson J, Brandsdal BO, Engqvist M, Flaten GE, Svendsen JS, Stensen W. A synthetic antimicrobial peptidomimetic (LTX 109): stereochemical impact on membrane disruption. J Med Chem. 2011 Aug 25;54(16):5786-95. doi: 10.1021/jm200450h. PubMed PMID: 21732630. Scott RW, Tew GN. Mimics of Host Defense Proteins; Strategies for Translation to Therapeutic Applications. Curr Top Med Chem. 2017;17(5):576-589. Review. PubMed PMID: 27411325. Nilsson AC, Janson H, Wold H, Fugelli A, Andersson K, H?kang?rd C, Olsson P, Olsen WM. LTX-109 is a novel agent for nasal decolonization of methicillin-resistant and -sensitive Staphylococcus aureus. Antimicrob Agents Chemother. 2015 Jan;59(1):145-51. doi: 10.1128/AAC.03513-14. PubMed PMID: 25331699; PubMed Central PMCID: PMC4291342. Saravolatz LD, Pawlak J, Johnson L, Bonilla H, Saravolatz LD 2nd, Fakih MG, Fugelli A, Olsen WM. In vitro activities of LTX-109, a synthetic antimicrobial peptide, against methicillin-resistant, vancomycin-intermediate, vancomycin-resistant, daptomycin-nonsusceptible, and linezolid-nonsusceptible Staphylococcus aureus. Antimicrob Agents Chemother. 2012 Aug;56(8):4478-82. doi: 10.1128/AAC.00194-12. PubMed PMID: 22585222; PubMed Central PMCID: PMC3421571.