TargetMol

LXY6090

Product Code:
 
TAR-T27866
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-T27866-100mg100mgEnquire
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TAR-T27866-500mg500mgEnquire
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Further Information

Bioactivity:
LXY6090 is a HIF-1 inhibitor. LXY6090 inhibited the activity of HIF-1 and downregulated the protein level of HIF-1α in breast cancer cells. LXY6090 showed in vivo anticancer efficacy by decreasing the HIF-1α expression in nude mice bearing MX-1 tumor xenografts.
CAS:
T27866
Molecular Weight:
580.68
Purity:
0.98
SMILES:
O=C(COC1=CC=C([C@@H]2C[C@H](C3=CC=C(OCC(NC4=CC=CC=C4)=O)C(OC)=C3)CC2)C=C1OC)NC5=CC=CC=C5

References

Lai F, Liu Q, Liu X, Ji M, Xie P, Chen X. LXY6090 - a novel manassantin A derivative - limits breast cancer growth through hypoxia-inducible factor-1 inhibition. Onco Targets Ther. 2016 Jun 24;9:3829-40. doi: 10.2147/OTT.S106925. eCollection 2016. PubMed PMID: 27445487; PubMed Central PMCID: PMC4928675.