TargetMol

JNJ525

Product Code:
 
TAR-T27687
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-T27687-100mg100mgEnquire
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TAR-T27687-500mg500mgEnquire
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Further Information

Bioactivity:
JNJ525 is an inhibitor of TNFα. JNJ525 inhibits protein function via an aggregation-based mechanism. JNJ525 prevents the formation of TNFα complexes with TNFR1 and TNFR2, the apparent IC50 values for the inhibition of complex formation are 1.2 ? 0.2 uM and 1.1 ? 0.1 uM respectively in the TR-FRET assay.
CAS:
T27687
Molecular Weight:
514.64
Purity:
0.98
SMILES:
NC1=NC=CC(N(CC2=CC=CC=C2)C(C=CC=C3)=C3C4=CC=CC(C5=CN=C(N6CCNCC6)N=C5)=C4)=N1

References

Structural Basis of Small-Molecule Aggregate Induced Inhibition of a Protein?Protein Interaction Jonathan M. BlevittMichael D. HackKrystal L. HermanPaul F. JacksonPaul J. KrawczukAlec D. LebsackAnnie X. LiuTaraneh MirzadeganMarina I. NelenAaron N. PatrickStefan SteinbacherMarcos E. Millaand Kevin J. Lumb Publication Date (Web): March 16, 2017 (Brief Article) doi: 10.1021/acs.jmedchem.6b01836