TargetMol

ICI 198615

Product Code:
 
TAR-T27576
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-T27576-100mg100mgEnquire
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TAR-T27576-500mg500mgEnquire
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Further Information

Bioactivity:
ICI 198615, a novel, potent and selective peptide leukotriene antagonist, may be useful for the the treatment of allergic diseases.
CAS:
104448-53-5
Molecular Weight:
548.61
Purity:
0.98
SMILES:
O=C(OC1CCCC1)NC=2C=CC=3C=NN(C3C2)CC4=CC=C(C=C4OC)C(=O)NS(=O)(=O)C=5C=CC=CC5

References

Smith EF 3rd, Slivjak MJ. ICI 198615 is an antagonist of leukotriene C4, leukotriene D4 and leukotriene E4 vasopressor responses in the conscious rat. Pharmacology. 1990;41(2):57-66. PubMed PMID: 2175920. Uchida Y, Hamada M, Kameyama M, Ohse H, Nomura A, Hasegawa S, Hirata F. ET-1 induced bronchoconstriction in the early phase but not late phase of anesthetized dogs is inhibited by indomethacin and ICI 198615. Biochem Biophys Res Commun. 1992 Mar 31;183(3):1197-202. PubMed PMID: 1567397.