TargetMol

FR 113680

Product Code:
 
TAR-T27360
Product Group:
 
Peptides
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
FR 113680 is a tripeptide substance P antagonist with NK1 receptor selectivity.
CAS:
126088-92-4
Molecular Weight:
625.726
Purity:
0.98
SMILES:
C[C@@H](O)[C@H](NC(C)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1

References

Caliendo G, Calignano A, Grieco P, Mancuso F, Perissutti E, Santini A, Santagada V. Synthesis and biological activity of tripeptide FR113680 analogues containing unconventional amino acids. Biopolymers. 1995 Oct;36(4):409-14. PubMed PMID: 7578938. Hagiwara D, Miyake H, Igari N, Murano K, Morimoto H, Murai M, Fujii T, Matsuo M. Design of a novel dipeptide substance P antagonist FK888. Regul Pept. 1993 Jul 2;46(1-2):332-4. PubMed PMID: 7692528. Morimoto H, Yamashita M, Matsuda A, Miyake H, Fujii T. Effects of FR 113680 and FK 224, novel tachykinin receptor antagonists, on cigarette smoke-induced rat tracheal plasma extravasation. Eur J Pharmacol. 1992 Nov 24;224(1):1-5. PubMed PMID: 1280594. Caliendo G, Greco G, Grieco P, Perissutti E, Santagada V, Calignano A, Mancuso F, Novellino E. Synthesis and in vitro activities of highly potent and selective tripeptide antagonists of the neurokinin NK-1 receptor. Farmaco. 1995 Nov;50(11):755-9. PubMed PMID: 8593172.