TargetMol

RA VII

Product Code:
 
TAR-T26028
Product Group:
 
Peptides
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
RA VII is used as an antitumor bicyclic hexapeptide of plant origin.
CAS:
86229-97-2
Molecular Weight:
770.884
Purity:
0.98
SMILES:
[H][C@]12Cc3ccc(OC)c(Oc4ccc(C[C@]([H])(N(C)C(=O)[C@H](C)NC(=O)[C@H](Cc5ccc(OC)cc5)N(C)C(=O)[C@H](C)NC(=O)[C@@H](C)NC1=O)C(=O)N2C)cc4)c3

References

Hasuda T, Hitotsuyanagi Y, Takeya K. Production of monoclonal antibodies against antitumor cyclohexapeptide RA-VII from Rubia cordifolia and their characterization. J Nat Med. 2011 Jul;65(3-4):588-93. doi: 10.1007/s11418-011-0508-z. Epub 2011 Feb 8. PubMed PMID: 21301980. Hitotsuyanagi Y, Lee JE, Kato S, Kim IH, Kohashi H, Fukaya H, Takeya K. Per-N-methylated analogues of an antitumor bicyclic hexapeptide RA-VII. Bioorg Med Chem. 2011 Apr 1;19(7):2458-63. doi: 10.1016/j.bmc.2011.02.003. Epub 2011 Mar 5. PubMed PMID: 21382716. Hasuda T, Hitotsuyanagi Y, Shinada M, Takeya K. Synthesis of [Tyr-5-?(CH2NMe)-Tyr-6]RA-VII, a reduced peptide bond analogue of RA-VII, an antitumor bicyclic hexapeptide. Bioorg Med Chem Lett. 2012 Apr 15;22(8):2757-9. doi: 10.1016/j.bmcl.2012.02.093. Epub 2012 Mar 3. PubMed PMID: 22460024. Hitotsuyanagi Y, Miyazawa A, Hinosawa TA, Nakagawa Y, Hasuda T, Takeya K. Aza-cycloisodityrosine analogue of RA-VII, an antitumor bicyclic hexapeptide. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6728-31. doi: 10.1016/j.bmcl.2013.10.033. Epub 2013 Oct 26. PubMed PMID: 24268554.