TargetMol

H 142

Product Code:
 
TAR-T25479
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
H 142 is a human renin decapeptide inhibitor.
CAS:
85139-12-4
Molecular Weight:
1210.47
Purity:
0.98
SMILES:
C([C@H](CC1=CN=CN1)NC(=O)[C@@H]2CCCN2)(=O)N3[C@H](C(N[C@@H](CC4=CC=CC=C4)C(N[C@@H](CC5=CN=CN5)C(N[C@H](CN[C@H](C(N[C@H](C(N[C@@H](CC6=CN=CN6)C(N[C@@H](CCCCN)C(O)=O)=O)=O)[C@H](CC)C)=O)C(C)C)CC(C)C)=O)=O)=O)CCC3

References

Tree M, Atrash B, Donovan B, Gamble J, Hallett A, Hughes M, Jones DM, Leckie B, Lever AF, Morton JJ, et al. New inhibitors of human renin tested in vitro and in vivo in the anaesthetized baboon. J Hypertens. 1983 Dec;1(4):399-403. PubMed PMID: 6398331. Hofbauer KG, M?nard J, Michel JB, Wood JM. Inhibition of renin in the primate Callithrix jacchus (common marmoset). Clin Exp Hypertens A. 1983;5(7-8):1237-47. PubMed PMID: 6196144. Tree M, Szelke M, Leckie B, Atrash B, Donovan B, Hallett A, Jones DM, Lever AF, Morton JJ, Sueiras-Diaz J, et al. Renin inhibitors: their use in understanding the role of angiotensin II as a pressor hormone. J Cardiovasc Pharmacol. 1985;7 Suppl 4:S49-52. PubMed PMID: 2412013. Webb DJ, Cumming AM, Leckie BJ, Lever AF, Morton JJ, Robertson JI, Szelke M, Donovan B. Reduction of blood pressure in man with H-142, a potent new renin inhibitor. Lancet. 1983 Dec 24-31;2(8365-66):1486-7. PubMed PMID: 6140568.