TargetMol

Fosinopril

Product Code:
 
TAR-T20520
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-T20520-100mg100mgEnquire
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Further Information

Bioactivity:
Fosinopril, a phosphinic acid-containing angiotensin-converting enzyme inhibitor, is effective in hypertension treatment. Fosinopril is a prodrug that is converted to its active metabolite fosinoprilat.
CAS:
98048-97-6
Molecular Weight:
563.6625
Purity:
0.98
SMILES:
CCC(=O)O[C@@H](OP(=O)(CCCCc1ccccc1)CC(=O)N1C[C@@H](C[C@H]1C(O)=O)C1CCCCC1)C(C)C

References

Huang ZB, Fang C, Lin MH, Yuan GY, Zhou SX, Wu W. Effect of fosinopril on the transient outward potassium current of hypertrophied left ventricular myocardium in the spontaneously hypertensive rat. Naunyn Schmiedebergs Arch Pharmacol. 2014 May;387(5):419-25. doi: 10.1007/s00210-014-0956-6. Epub 2014 Jan 19. PubMed PMID: 24441766. Huang ZB, Deng CY, Lin MH, Yuan GY, Wu W. Fosinopril improves the electrophysiological characteristics of left ventricular hypertrophic myocardium in spontaneously hypertensive rats. Naunyn Schmiedebergs Arch Pharmacol. 2014 Nov;387(11):1037-44. doi: 10.1007/s00210-014-1024-y. Epub 2014 Jul 27. PubMed PMID: 25064464. Uutela P, Monto M, Iso-Mustaj?rvi I, Madetoja M, Yliperttula M, Ketola RA. Identification of metabolites of fosinopril produced by human and rat liver microsomes with liquid chromatography-mass spectrometry. Eur J Pharm Sci. 2014 Mar 12;53:86-94. doi: 10.1016/j.ejps.2013.12.009. Epub 2013 Dec 21. PubMed PMID: 24365260. Xue K, Li G, Sun X, Hu Y, Hu L, Huang J, Si L. Simultaneous quantification of fosinopril and its active metabolite fosinoprilat in rat plasma by UFLC-MS/MS: Application of formic acid in the stabilization of an ester-containing drug. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 May 15;990:141-9. doi: 10.1016/j.jchromb.2015.03.028. Epub 2015 Apr 3. PubMed PMID: 25875586.