TargetMol

GS-566500

Product Code:
 
TAR-T20160
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-T20160-100mg100mgEnquire
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This product comes from: United States.
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Further Information

Bioactivity:
GS-566500 is a compound of Sofosbuvir metabolite.
CAS:
1233335-78-8
Molecular Weight:
411.27
Purity:
0.98
SMILES:
C[C@]1(F)[C@@H](O[C@H](COP(N[C@H](C(O)=O)C)(=O)O)[C@H]1O)N2C(=O)NC(=O)C=C2

References

Lawitz E, Rodriguez-Torres M, Denning JM, Albanis E, Cornpropst M, Berrey MM, Symonds WT. Pharmacokinetics, pharmacodynamics, and tolerability of GS-9851, a nucleotide analog polymerase inhibitor, following multiple ascending doses in patients with chronic hepatitis C infection. Antimicrob Agents Chemother. 2013 Mar;57(3):1209-17. doi: 10.1128/AAC.01263-12. Epub 2012 Dec 21. PubMed PMID: 23263000; PubMed Central PMCID: PMC3591915. Custodio JM, Chuck SK, Chu H, Cao H, Ma G, Flaherty J, Ling J, Kearney BP. Lack of clinically important PK interaction between coformulated ledipasvir/sofosbuvir and rilpivirine/emtricitabine/tenofovir alafenamide. Pharmacol Res Perspect. 2017 Oct;5(5). doi: 10.1002/prp2.353. PubMed PMID: 28971607; PubMed Central PMCID: PMC5625157. Denning J, Cornpropst M, Flach SD, Berrey MM, Symonds WT. Pharmacokinetics, safety, and tolerability of GS-9851, a nucleotide analog polymerase inhibitor for hepatitis C virus, following single ascending doses in healthy subjects. Antimicrob Agents Chemother. 2013 Mar;57(3):1201-8. doi: 10.1128/AAC.01262-12. Epub 2012 Dec 21. PubMed PMID: 23262999; PubMed Central PMCID: PMC3591883.