TargetMol

SNIPER(ABL)-047

Product Code:
 
TAR-T18692
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
SNIPER(ABL)-047, conjugating HG-7-85-01 (ABL inhibitor) to MV-1 (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 2 uM[1].
CAS:
T18692
Molecular Weight:
1274.5
Purity:
0.98
SMILES:
CCN1CCN(CC2=C(C(F)(F)F)C=C(NC(C3=CC(C4=NC5=C(N=C(NC(COCCOCCOCCNC([C@H](C(C6=CC=CC=C6)C7=CC=CC=C7)NC([C@H]8N(C([C@@H](NC([C@H](C)NC)=O)C9CCCCC9)=O)CCC8)=O)=O)=O)S5)C=C4)=CC=C3)=O)C=C2)CC1

References

Shibata N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017 Aug;108(8):1657-1666.