TargetMol

MC-Val-Cit-PAB-Indibulin

Product Code:
 
TAR-T18325
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-T18325-100mg100mgEnquire
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TAR-T18325-500mg500mgEnquire
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Further Information

Bioactivity:
MC-Val-Cit-PAB-Indibulin is a drug-linker conjugate for ADC with potent antitumor activity by using Indibulin (an orally applicable inhibitor of tubulin assembly), linked via the ADC linker MC-Val-Cit-PAB.
CAS:
2055896-95-0
Molecular Weight:
945.48
Purity:
0.98
SMILES:
C(C(NC=1C=C[N+](CC2=CC=C(NC([C@@H](NC([C@@H](NC(CCCCCN3C(=O)C=CC3=O)=O)[C@H](C)C)=O)CCCNC(N)=O)=O)C=C2)=CC1)=O)(=O)C=4C=5C(N(CC6=CC=C(Cl)C=C6)C4)=CC=CC5

References

Staben LR, et al. Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody-drug conjugates. Nat Chem. 2016 Dec;8(12):1112-1119.