TargetMol

Mc-Leu-Gly-Arg

Product Code:
 
TAR-T18309
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
 

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TAR-T18309-100mg100mgEnquire
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Further Information

Bioactivity:
Mc-Leu-Gly-Arg is a cleavable ether linker for antibody-drug conjugates (ADC) design.
CAS:
T18309
Molecular Weight:
466.53
Purity:
0.98
SMILES:
O=C(O)[C@H](CCCNC(N)=N)NC([C@H](C(C)C)NC(CCCCCN(-;@C1=O)-;@C(-;@C=;@C-;@1)=O)=O)=O

References

Zhang D, et al. Immolation of p-Aminobenzyl Ether Linker and Payload Potency and Stability Determine the Cell-Killing Activity of Antibody-Drug Conjugates with Phenol-Containing Payloads. Bioconjug Chem. 2018 Feb 21;29(2):267-274.