TargetMol

K-Ras ligand-Linker Conjugate 2

Product Code:
 
TAR-T18055
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
K-Ras ligand-Linker Conjugate 2 is a chemical compound that includes a ligand for K-Ras and a PROTAC linker. This compound is capable of recruiting E3 ligases like VHL, CRBN, MDM2, and IAP. It is utilized in the synthesis of PROTAC K-Ras Degrader-1, which is a highly effective PROTAC K-Ras degrader with a degradation efficacy of ≥70% in SW1573 cells[1].
CAS:
T18055
Molecular Weight:
822.99
Purity:
0.98
SMILES:
NCCOCCOCCOCCO[C@H]1CN(C)[C@H](COC2=NC3=C(CCN(C4=CC=CC5=C4C=CC=C5)C3)C(N6CCN(C(OCC7=CC=CC=C7)=O)[C@@H](CC#N)C6)=N2)C1

References

CREW, Andrew P., et al. MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE. WO2019195609A2.