TargetMol

Gemcitabine-O-Si(di-iso)-O-Mc

Product Code:
 
TAR-T17985
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
Gemcitabine-O-Si(di-iso)-O-Mc is a drug-linker conjugate for ADC with potent antitumor activity by using Gemcitabine (a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent), linked via the ADC linker[1].
CAS:
T17985
Molecular Weight:
558.65
Purity:
0.98
SMILES:
NC(C=CN1[C@H]2C(F)([C@@H]([C@H](O2)CO[Si](C(C)C)(OCCCCCN3C(C=CC3=O)=O)C(C)C)O)F)=NC1=O

References

Mathew C. Finniss, et al. A versatile acid-labile linker for antibody?drug conjugate. MedChemComm, Issue 9, 2014.