TargetMol

VHL Ligand-Linker Conjugates 15

Product Code:
 
TAR-T17908
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
VHL Ligand-Linker Conjugates 15 is a chemical compound that combines a VHL ligand, which targets the E3 ubiquitin ligase, with a PROTAC linker. It is specifically designed for the creation of PROTACs[1].
CAS:
2375564-62-6
Molecular Weight:
724.84
Purity:
0.98
SMILES:
C([C@@H](NC(=O)C1(F)CC1)C(C)(C)C)(=O)N2[C@H](C(NCC3=C(OCCOC4=CC=C(C=C4)C5OCCO5)C=C(C=C3)C=6SC=NC6C)=O)C[C@@H](O)C2

References

Farnaby W, et al. BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design. Nat Chem Biol. 2019 Jul;15(7):672-680.