TargetMol

E3 ligase Ligand 9

Product Code:
 
TAR-T17880
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
E3 ligase Ligand 9 is a compound that serves as a ligand for E3 ubiquitin ligase. It can be linked to the protein ligand through a linker, forming PROTACs or SNIPERs. These PROTACs are known to induce the degradation of cancer-promoting proteins through ubiquitination-mediated mechanisms[1].
CAS:
87304-15-2
Molecular Weight:
408.49
Purity:
0.98
SMILES:
[C@@H](CC1=CC=CC=C1)([C@@H](C(N[C@@H](CC(C)C)C(O)=O)=O)O)NC(OC(C)(C)C)=O

References

Shibata N, et al. Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands. J Med Chem. 2018 Jan 25;61(2):543-575.