TargetMol

Tos-PEG2-O-Propargyl

Product Code:
 
TAR-T17125
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
Tos-PEG2-O-Propargyl is a polyethylene glycol (PEG)-based proteolysis targeting chimera (PROTAC) linker, commonly employed for the synthesis of Thalidomide-O-PEG2-propargyl[1].
CAS:
1119249-30-7
Formula:
C14H18O5S
Molecular Weight:
298.36
Purity:
0.98
SMILES:
O=S(=O)(OCCOCCOCC#C)C1=CC=C(C=C1)C

References

Wurz RP, et al. A "Click Chemistry Platform" for the Rapid Synthesis of Bispecific Molecules for Inducing Protein Degradation. J Med Chem. 2018 Jan 25;61(2):453-461.