TargetMol

Propargyl-PEG4-acid

Product Code:
 
TAR-T16614
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-T16614-500mg500mgEnquire
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This product comes from: United States.
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Further Information

Bioactivity:
Propargyl-PEG4-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-IAP PROTACs Ibrutinib -based PROTAC 2 and an analogue PROTAC 3. PROTAC 3 causes BTK degradation with a DC50 of 200 nM in THP-1 cells[1].
CAS:
1415800-32-6
Formula:
C12H20O6
Molecular Weight:
260.28
Purity:
0.98
SMILES:
O=C(O)CCOCCOCCOCCOCC#C

References

Tinworth CP, et al. PROTAC-Mediated Degradation of Bruton's Tyrosine Kinase Is Inhibited by Covalent Binding. ACS Chem Biol. 2019 Mar 15;14(3):342-347.