TargetMol

N3-PEG3-CH2CH2-Boc

Product Code:
 
TAR-T16257
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-T16257-500mg500mgEnquire
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Further Information

Bioactivity:
N3-PEG3-CH2CH2-Boc is a cleavable 3 unit polyethylene glycol (PEG) ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs)[1]. This compound also functions as a PEG- and alkyl/ether-based PROteolysis TArgeting Chimera (PROTAC) linker, suitable for the construction of PROTAC molecules[2].
CAS:
252881-73-5
Formula:
C13H25N3O5
Molecular Weight:
303.35
Purity:
0.98
SMILES:
[N-]=[N+]=NCCOCCOCCOCCC(=O)OC(C)(C)C

References

Peng L, et al. Identification of New Small-Molecule Inducers of Estrogen-related Receptor ? (ERR?) Degradation. ACS Med Chem Lett. 2019 Apr 12;10(5):767-772. Yongxin Robert ZHAO, et al. Conjugation linkers, cell binding molecule-drug conjugates containing the likers, methods of making and uses such conjugates with the linkers. WO2018086139A1.