TargetMol

Azido-PEG6-NHS ester

Product Code:
 
TAR-T14470
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
Azido-PEG6-NHS ester is a cleavable 6 unit polyethylene glycol (PEG) linker, commonly employed in the synthesis of antibody-drug conjugates (ADCs)[1]. Additionally, it serves as a PEG- and alkyl/ether based linker for the synthesis of proteolysis targeting chimeras (PROTACs)[2].
CAS:
2055014-64-5
Formula:
C19H32N4O10
Molecular Weight:
476.48
Purity:
0.98
SMILES:
[N-]=[N+]=NCCOCCOCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O

References

Thiele NA, et al. An Eighteen-Membered Macrocyclic Ligand for Actinium-225 Targeted Alpha Therapy. Angew Chem Int Ed Engl. 2017 Nov 13;56(46):14712-14717. John W. Babich, et al. Trifunctional constructs with tunable pharmacokinetics useful in imaging and anti-tumor therapies. WO2018187631A1.