TargetMol

Tubulysin G

Product Code:
 
TAR-T13941
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
Tubulysin G is a natural product isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis, and is a highly cytotoxic peptide. Tubulysin G is a cytotoxic activity tubulysin that inhibits tubulin polymerization and leads to cell cycle arrest and apoptosis.
CAS:
799822-08-5
Formula:
C43H63N5O10S
Molecular Weight:
842.05
Purity:
0.98
SMILES:
N([C@H](C[C@@H](OC(C)=O)C1=NC(C(N[C@@H](CC2=CC=C(O)C=C2)C[C@@H](C(O)=O)C)=O)=CS1)C(C)C)(C([C@@H](NC(=O)[C@@H]3N(C)CCCC3)[C@H](CC)C)=O)COC(C=C(C)C)=O

References

Vlahov IR, et al. Acid mediated formation of an N-acyliminium ion from tubulysins: a new methodology for the synthesis of natural tubulysins and their analogs. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6778-81. Kubicek K, et al. The tubulin-bound structure of the antimitotic drug tubulysin. Angew Chem Int Ed Engl. 2010 Jun 28;49(28):4809-12.